The rates come from REACLIB, the library of reaction rates maintained by JINA, as pynucastro distributes it: for each reaction a seven-parameter formula fitted to the measured or calculated rate, with its source. Your browser evaluates that same formula. For reactions between charged nuclei the steepness comes from the Coulomb barrier: only the nuclei in the Gamow window take part, and a hotter gas has many more of them.
A nucleus's waiting time is one over the chance per second that a reaction transforms it: it depends on the rate, on the density and on how many partners are around (protons, nearly always). For a decay it is the mean life, the half-life divided by ln 2. In a cycle the slowest step rules: 14N(p,γ)15O in the CNO cycle, the fusion of two protons in the pp chain. Where a nucleus can go two ways the faster one wins, so the slowest step is taken along the path the flow follows: in a nova, 13N captures a proton long before it decays.
“What if” reruns the burn in a one-zone model: fixed temperature and density, the scenario's initial composition, and the network integrated in time with an implicit method, in a separate thread of your browser. The result is compared with the burn at the original rates. A one-zone model shows which reactions matter, and how much; it does not replace a model of a star. Each scenario's values and their source are under “Where these numbers come from”.